Hello Mike- My only experience with Pass Labs has been with the X260.8. I would imagine that the x350.8 would have similar characteristics. My MXR's are not the Twenty, only my KXR Twenty is the updated version, although it started out as a basic KXR, and I sent it in for the update. I considered doing so with the MXR's. but came to realize that they didn't have enough headroom to really handle the difficult load presented by my electrostatic panels. I was often running the volume control on the KXR at or near 50, the max, and sometimes having them overheat and go into protection. The Pass Lab x260.8's seem to have more oomph, and never run out of steam. I believe they are capable of delivering more current, which is what Sound Labs need. This has resulted in a more relaxed presentation, more solid bass, and more air around voices and instruments. The Ayre amps are rated at 300 watts, and the Pass Labs at 260, but I believe more current is available, and thus the ease. Furthermore, I believe they remain in Class A deeper into the music, with little Class B power being required, whereas the Ayre amps probably switch over to Class B sooner. If I could tolerate the heat, cost, and power consumption of a pure Class A Pass Lab amp, such as the XA200.8 ($42,000) I suspect I would be even happier.
If your speakers are more efficient than mine, then the Ayre MXR's might be a better choice, as they should be capable of bettering the X260.8, considering the relative prices (MXR/$19k vs. X260.8/$13,500.) Should you still have an interest in the MXR's, mine are available at $8900. I actually own two pair, and will be keeping the 2nd pair for my 2nd (city) system.
Hope that helps,
Tom